The NHS is currently searching for a new partnership to run the Mandeville surgery in Aylesbury.
In October the partners who previously ran the surgery gave six months notice that they intended to stop running it.
NHS England says that it is now in talks with other providers, and that when that time has elapsed they will put interim management in place.
A spokesman said: “Information will be available at the practice about how you can get involved with the appointment of the interim provider and the future services to be provided by The Mandeville Practice.
“All of the practice staff will be able to transfer their employment to the new GP services provider.
“Patients will be kept updated via the practice website and information posted in the practice. Patients will be informed when NHS England has identified the interim provider to run the practice from April 2016.”
A letter to patients and stakeholders from the Aylesbury Vale Clinical Commissioning group, read: “Despite a great deal of effort and much consideration, the partners at The Mandeville Practice in Aylesbury have taken the decision to end their GP partnership.”
It added: “Every option has been explored to avoid this outcome and the partners are incredibly sad to have to do this.”