A man and a woman were trapped and injured, following a collision involving a car and a van in Quainton.
The firefighters provided immediate emergency care to the two people who were trapped, and used hydraulic rescue equipment to release them both.
They were then passed into the care of South Central Ambulance Service.
SCAS sent two ambulance crews who assessed and treated the two casualties at the scene.
One patient was then taken to Stoke Mandeville Hospital, while the other did not require hospital treatment.