A bus and a car have been involved in a crash near the Bourg Walk junction in Friarage Road, Aylesbury.
It appears the Water Rider bus was beginning to cross Friarage Road towards the bus station when it hit the side of a silver Peugeot 206 which was heading towards Oxford Road.
Police officers were called to the scene at 3.30pm and closed the road to allow ambulance crews to tend to the people involved.
Firefighters have released a female passenger from the car and she has been taken to hospital with what are believed to be minor injuries.
A passenger on the bus has been treated with minor injuries and was discharged at the scene.
A police spokesman has confirmed that officers are about to reopen the road but the incident is still causing tailbacks and drivers are being advised to avoid the area.