Police are investigating an explosion at an address in Sewell Close, Haydon Hill, which left a man hospitalised with serious burns.
Emergency services were called to the incident at around 3.30pm on Sunday.
A 34-year-old male was found inside the house, and was taken to Stoke Mandeville hospital suffering from burns to his body.
He remains in hospital and is said to be in a serious condition.
Three fire crews attended the blaze, which police say they are treating as an isolated incident.