Two young children were flown to hospital by two separate air ambulance crews after the fatal A41 crash yesterday.
The youngsters were injured alongside five other children when the Toyota Landcruiser they were travelling in collided with a white Vauxhall and a grey Renault near Waddesdon.
Paramedics pronounced the female driver of the Vauxhall dead at the scene. She is thought to be a young woman in her late teens from the local area.
The Warwickshire and Northamptonshire Air Ambulance arrived in 12 minutes to treat a young boy who had suffered pelvis and chest injuries.
He was carefully immobilised by the crew before being airlifted to John Radcliffe Hospital in Oxford for further treatment.
Another child was airlifted to the same hospital by the Thames Valley and Chiltern Air Ambulance, and both remain in a serious condition.
Two other children were transferred by land ambulance to John Radcliffe Hospital, and the three remaining children were taken by road to Stoke Mandeville Hospital.
Police are appealing for any witnesses to the tragic crash to get in touch.
You can contact Thames Valley Police by calling 101.